Cost-Effectiveness Studies

A number of published studies highlight the cost savings that can be achieved in TB control when the T-SPOT.TB test is implemented.

“Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis1” published in the International Journal of TB and Lung Disease developed a LTBI screening model to perform a cost-effectiveness comparison of TST, T-SPOT.TB test and an ELISA IGRA test. Additional costs of adverse drug reactions (isoniazid-related hepatotoxicity) and post-exposure TB were taken into account. The overall cost per case of active TB prevented was used as the primary outcome measure.

The results for a 2 years period of screening of a cohort of 1,000 individuals using either a single (TST or IGRA) or dual (TST followed by IGRA) strategy showed that T-SPOT.TB test -based strategies were more cost effective, when used in single or dual strategies, than the TST or ELISA based IGRAs when used in single or dual strategies.

“Direct costs of three models for screening of latent tuberculosis infection2” published in the European Respiratory Journal analyzes short term direct costs. The study shows that the most cost effective model is to include T-SPOT.TB into the screening algorithm.

“Cost-effectiveness of IGRA testing for the treatment of latent tuberculosis infection in Switzerland3” published in the European Respiratory Journal uses a Markov model to calculate the cost effectiveness of different screening strategies used for contact tracing. The study shows that T-SPOT.TB based screening is cost effective compared to doing no screening or running TST based control programs. Also the use of T-SPOT.TB, either alone or in combination with TST, greatly reduces the number of contacts treated to prevent one TB case.

“Cost effectiveness of TB testing – health economic evaluation4” produced by the York Health Economics Consortium looked at longer term costs. Their analysis showes that when all costs are considered, the T-SPOT.TB test is the least expensive testing strategy. Additionally, T-SPOT.TB is the most effective strategy in improving the health-related well being of potential TB patients.

1. Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis Pooran,et al . Int J Tuberc Lung Dis. 2009 Nov; 13(11):1427-32. BMC Pulmonary Medicine 2010, 10:7 doi:10.1186/1471-2466-10-7

2Direct costs of three models for the screening of latent tuberculosis infection Wrighton-Smith P and Zellweger J-P, Eur Respir J 2006; 28: 45-50.

3Cost-effectiveness of IGRA testing for the treatment of latent tuberculosis infection in Switzerland. Diel et al.  ERJ 2007 30: 321-332.

4Cost effectiveness of TB testing – a health economic evaluation York Health Economics Consortium Ltd., West P et al., 2005..