The T-SPOT.TB test is a cost effective solution for TB screening when compared to the significant costs associated with the tuberculin skin test (TST). Total costs for the tuberculin skin test are often believed to be lower than the actual cost. According to a published study by Lambert et al., the total cost of a tuberculin skin test per healthcare worker tested ranged from $41.00USD to $362.00USD.3
Some of the tuberculin skin test’s less obvious costs include:
The T-SPOT.TB test addresses the sources of these costs associated with the TST:
The table below highlights the most signficant cost savings:
|Annual Healthcare Worker (HCW) Screening1,2||One Visit
|New HCW screening||One Visit
(Two-step testing)*1st Test:
|Patient testing||One Visit
|BCG vaccinated patient or HCW||Results are not affected by BCG vaccine||Cross-reacts with BCG vaccine.Cost of false positive result:
|Immunosuppressed patient or HCW||Results are not affected by immunosuppression||Results are affected by immunosuppression.Cost of false negative result:
|Subjects miss clinics||Only one visit required||Two visits are required. Up to one third of subjects do not return for test interpretation|
|Un-used reagents||Only use sufficient reagents for each test||PPD must be used within one day of opening. Un-used PPD is discarded
1Wrighton-Smith P, et al., Screening Health Care Workers With Interferon-γ Release Assay Versus Tuberculin Skin Test. JOEM Volume 54, Number 7, July 2012
2Eralp MN, et al., Screening of healthcare workers for tuberculosis: development and validation of a new health economic model to inform practice. BMJ Open. 2012 Mar 1;2(2)
31Lambert L et al., Costs of Implementing and Maintaing a Tuberculin Skin Test Program in Hospitals and Health Departments. Inf Con and Hosp Epidm 2003: 814-821
.4Lee J et al., Comparison of two commercial interferon-gamma assays for diagnosing Mycobacterium tuberculosis infection. Eur Respir J 2006: 28: 24-30.
5T-SPOT.TB Pivotal Clinical Study. T-SPOT.TB results were not associated with immunocompromised status. T-SPOT.TB Package Insert.
To see a summary of key clinical studies, here.